The two teams are vying for top spot in Group G but that won't stop Southgate from introducing a host of changes, with Jamie Vardy, Marcus Rashford, Trent Alexander-Arnold, Eric Dier and Gary Cahill all expected to start.
Germany lost 2-0 to South Korea on Wednesday afternoon, meaning the holders finished bottom of Group F. It is the first time since 1938 that a Germany or West Germany side has not progressed beyond the first section of the tournament.
"We need to keep winning football matches and we want to breed a mentality that everybody in our squad wants to constantly win", he told reporters. We've not won a knockout game since 2006, so why we are starting to plot which would be a better venue for our semifinal is beyond me, really.
"I said to him, "Alright, we've got 10 minutes to go, when I give a free-kick against you" - and I knew I would because he's that sort of player - 'just leather the ball 50 yards away and I can caution you for dissent'".
The final matchday of Group G likely won't match the drama of Germany's shocking exit and Sweden's dominant triumph over Mexico, as both Belgium and England have already qualified for the Round of 16 by winning their first two games of group play.
But in Belgium they face the world's third-ranked side, and a squad loaded with world-class talent such as Eden Hazard and Kevin De Bruyne.
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However, in the second-half, the game sprung to life without the Selecao being at their fluent best. There wasn't a blue shirt within 10 yards of it to connect for a shot.
However, it was never proved if the match was thrown, but henceforth all final group matches were played together.
However, while England and Belgium have been scoring freely, they have also conceded some goals which looked rather unwarranted. "At that point it was one or the other", the ex-Wigan Athletic and Everton manager added.
He said: "For tomorrow I hope it will be a good game because I'm afraid second place may be better in the group".
"That's the reality. We wanted to qualify, we've done that".
"We have to go out to play well in every game and to try and win every game".
They finished runners-up to Croatia and are now seeded on the same side of the bracket as whoever wins Group G.
"There are players with yellow cards, and I don't think it would be professional for us to put those players in a risk to miss the knockout phase".