Despite all three players being in their 30s, they have now won all eight Grand Slams since Stan Wawrinka won the 2016 U.S. Open.
Something in the Alpine air clearly agreed with him, though, and he went on to triumph at Wimbledon, the U.S. Open tune-up in Cincinnati and then in NY to grab his 14th career Grand Slam title, putting him third on the all-time list.
With this win, he has equaled Pete Sampras's mark of 14 Grand Slams.
Djokovic, playing in his eighth final in NY and already the champion in 2011 and 2015, is now just three Slams behind Rafael Nadal and six back from the record 20 held by Roger Federer.
Del Potro was looking to win his first slam title for nine years but Djokovic proved too strong, the Serbian prevailing 6-3 7-6 (7/4) 6-3 to add to his Wimbledon crown.
However, Del Potro and his mighty forehand came to the party, striking back in spectacular fashion to level at 3-3, while the support for the giant Argentine appeared to rattle Djokovic's concentration levels.
The Serb, who was back in the final for an eighth time and contesting his 23rd Grand Slam final - the third most in men's tennis history - was serving exceptionally well and earned a break in the eighth game after showing tremendous patience before successfully serving out the set. After the third round, he did not lose a single set as he was able to outlast a fan favorite in Del Potro. "To be honest, I was crying till now", Del Potro said as he began his post-match press conference.
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"Maybe 10 years ago, I would say I'm not so happy to be part of this era with Nadal and Federer". The US Open winners have been crowned. He was earmarked as the next big force, the man alongside Djokovic to rattle the two great champions he had just felled to break through.
It was only the second set dropped by the Argentine at the tournament.
"I was so close to desired level, and then I just completely underplayed that match". For Djokovic, it was an illustration of him growing into the championships as he took his run of consecutive sets won to 14, stretching back to the second round against Tennys Sandgren. Three times, Djokovic steeled himself.
That's 85 percent. Quite a contrast to the current state of the women's game, where eight players won the past eight majors. I had my opportunities during second and third set.
But he is a strong candidate for any title when he is fit and the fact he has the most number of victories by anyone over world number one player just goes to show how unsafe he can become when he is without any injury.
After Djokovic, 31, watched them increase their advantages over him while he went more than 2 years without a major, hampered by an injured right elbow that required surgery in February, he is now got his game in order.