He limped off after scoring in their 2-0 win over Brighton on Saturday but still took part in training. Kevin De Bruyne is back in training, but not yet fit enough to play, while Benjamin Mendy is also out.
That starting eleven is likely to be fitted into a similar system favoured to past year, with Ederson guaranteed to line up in goal as the Brazilian 'keeper is the only senior goalkeeper available, with Kyle Walker and Fabian Delph on either flank. The side finished fourth in the Bundesliga last season.
Hoffenheim captain Kevin Vogt is set to miss out due to a thigh injury. Inexperienced trio Stefan Posch (21), Kevin Akpoguma (23) and Justin Hoogma (20) deputise once more.
But the broader question concerns how Pep Guardiola's men will bounce back from their shock 2-1 home defeat to Lyon in their Group F opener.
"I don't want to talk about officials", insisted the City boss.
This will be the first ever meeting in any competition between Hoffenheim and Manchester City.
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Flake said he would "only be comfortable moving on the floor until the FBI has done more investigation than they have already". But she stressed that experience as an activist does not matter in situations like her confrontation with Flake.
The visitors continued to dominate the match thereafter even as the talented attack-line attempted to break Hoffenheim's stubborn defence.
However, the lead was short-lived as Sergio Aguero leveled scores for Man City, six minutes later to make it 1-1. Guardiola was in charge of Bayern that day. "It's maybe at this point the biggest one in the Premier League".
The rude awakening City endured offered another timely reminder of their frailties in away Champions League matches.
The Argentinian had a total of seven chances, five in the first-half alone, and moments later Hoffenheim goalkeeper Oliver Baumann had to palm yet another Aguero shot over the crossbar. Manchester City have rotated the centre-backs and tried different players at left-back a fair amount already. Aguero both scored and assisted in his last Champions League away game v Basel in February 2018.
It may be a stretch to say the loss to Lyon had derailed City's bid for the most sought-after trophy in European football, but it certainly cast further doubts over their pedigree in this tournament.
Despite losing their opening match, City are still favourites to go through from Group F.