But De Bruyne appeared to hurt his left knee in a tussle with Fulham defender Timothy Fosu-Mensah and left the pitch shortly after the incident.
"Yesterday he came back in many, many things".
"We don't know if it's nothing or if it's something serious".
Guardiola said at the final whistle: "He is being checked by the doctors". We were clever and made the space and created enough chances.
"He knows the desire we want for all young players", Guardiola added.
Hughes has reported no fresh injury problems for Saints with Danish midfielder Hojbjerg resuming full training after missing the goalless draw with Newcastle through illness.
Brahim Díaz scored twice on Thursday as Manchester City beat Fulham to reach the last eight of the League Cup in England.
Rocco Baldelli is the new Twins manager and it’s a ideal hire
Baldelli will be the first major league manager born in the 1980s. "But I also know that I do have to take care of myself". The 37-year-old was previously employed as Tampa Bay's first base coach and worked in the team's scouting department.
According to a UK Sun report, the Belgium midfielder, who has already been sidelined with for six weeks this term, will see out another four weeks of football action.
De Bruyne was making just his second start of the season, though City have moved top of the Premier League without him.
It was the only sour moment on a comfortable night for City as they eased into the quarterfinals of the Carabao Cup.
If he does miss that clash he could return for the home games against Hoffenheim or Everton in mid-December.
I'm going to go 4-0. Southampton haven't scored since I was 11, I don't think. Everyone here is ready to play in the first team, otherwise, he wouldn't be here.