Combined, the deaths bring the number of USA troops killed in combat in Afghanistan this year to 13.
Three US service members will killed and three others wounded when an improvised explosive device detonated Tuesday near the central Afghan city of Ghazni, officials said. "One American contractor was also wounded", Resolute Support said in a statement.
The statement further added "The wounded service members and contractor were evacuated and are receiving medical care".
There was no word on the circumstances of the blast but Ghazni has been one of the most heavily fought over areas of Afghanistan this year.
The Taliban have an active presence in Ghazni province and tried to take over the capital in August.
There’s a turkey in the White House as Trump grants poultry pardons
It should be noted that even though the President pardons the turkeys, many animal-rights activists condemn the practice. Trump said in a nod to the recently resolved election turmoil in Florida and Georgia. "Too bad for "Carrots", he added".
The Taliban have intensified attacks on Afghan forces even as the United States ratchets up efforts to engage the militants in peace talks.
Resolute Support said that "an initial review indicates Sgt. Jasso was likely accidentally shot by our Afghan partner force" and "there are no indications he was shot intentionally". Last month CBS News joined US forces on the battlefield in Nangarhar Province.
On Sunday, the DOD had identified the soldier that was killed in the Garmsir District, Helmand Province, Afghanistan from "injuries sustained while engaging enemy forces" the day prior as Sgt. Leandro A.S. Jasso.
USA envoy Zalmay Khalilzad is spearheading efforts to strike a peace deal with the Taliban before Afghanistan's presidential election, scheduled for April next year. Brent Taylor was shot dead in an insider attack in Kabul. The great majority of US forces withdrew by the end of 2014, but those still in the country often are involved in supporting combat situations on the ground as well as by air.
Since the start of 2015, 58 Americans have been killed, President Ashraf Ghani said earlier this month.
During that same period, 58 US troops were killed, he said.