Phil Foden, who was on the scoresheet at the weekend, is expected to continue in the middle of the park, while Ilkay Gundogan is expected to start again as well, after a sensational display in the previous game.
City went on to smash five more past Burton in the second period and Zinchenko revealed what Guardiola's instructions were at half-time.
One positive may be that they stopped City reaching 10, a feat Fulham were unable to manage against Liverpool in the competition in 1986.
Manchester United have one of the worst defensive records in the league this season after conceding 32 goals in just 21 games this term.
And the Belgian set the tone for the evening by heading City into a fifth-minute lead as he timed his run into the box perfectly to head home David Silva's cross.
"It's not very pleasant when you're on the other end of it, but I've just said to the players, if that front five players in the final of the Champions League. if they make it. they'll give Real Madrid problems or whoever problems, so they're going to give us problems".
Chinese phone maker Huawei punishes employees for iPhone tweet blunder
Reuters said it was able to obtain an internal company memo that detailed how the incident took place, as well as its aftermath. To circumvent the so-called Great Firewall of China, individuals and companies typically use virtual private networks ( VPN ).
Nigel Clough's side travel to the Etihad hoping to cause a monumental shock and take a positive result back to the Pirelli Stadium for the second leg. They have picked up 8 FA Cup trophies in their history, with their victory last year being their first in six years. We're not a team who has a lot of titles in our museum so you have to take these chances to get to the final.
Jesus headed home his first from close range after Bradley Collins had denied Leroy Sane before the Brazilian slotted home Silva's cushioned pass via the inside of the post.
"We do what we have to do to become a great, great club", warned Guardiola. "When they are on their own patch, as you saw against Liverpool, they're as good and as confident as anything".
Gabriel Jesus scored four goals for the first time in a City shirt and was named man of the match.
Jesus continued his troubling act on the hapless visitors by completing his hat-trick with a ideal header from close range on 57 minutes.
Mahrez made it nine seven minutes from time and those City fans still in the Etihad cried for a historic 10th.