Following Spurs' loss on Saturday, Solskjaer's side can go level on points with the North London club should they beat Arsenal at the Emirates.
Both teams boarded midweek flights across the English Channel to France for their respective European ties but the atmospheres on the flights back home highlighted a stark contrast.
That suggests Emery could make major changes from the side that lost 3-1 to Rennes in the Europa League on Thursday. A first-half red card to Greek defender Sokratis only added more misery to Unai Emery's men.
"Even with [Petr] Cech coming back - I can actually see why he's chose to say "I've had enough", because since he's came to Arsenal it's been nothing but hard work for him".
Shaw and Marcus Rashford combined down the left but the latter's cross was cut out before it could find Lukaku, and with half-time seconds away Diogo Dalot's cross was cleared before Rashford could get a touch.
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Their opponents, on the other hand, are fresh from making history by beating perennial French champions Paris St. Germain.
They had led 2-0 after the first-leg at Old Trafford in February, but Ole Gunnar Solskjaer's men completed a terrific turnaround to win the second-leg 3-1 at Paris.
Dalot struggled with form and injuries under Mourinho but, like many Manchester United players, has been given a new lease of life by Solskjaer. I don't criticise the referee but maybe if the VAR is coming, it can help.
Their manager cut an elated face as he praised his side after the match. It is a game that we know is very important for us but we will be ready. While these matches used to decide the title race, these days they tend to define which teams secure top-four berths come May. But in addition to providing an opportunity to enjoy high caliber play, tradition has become a positive experience that brings the team together to watch the sport we enjoy and to bond as a brotherhood.
"So to get that victory and turn that around, congratulations need to go to the entire squad because we were missing a lot of players".