Back in November the Citizens brushed aside their rivals 3-1 at the Etihad, meaning they've now won three of the last five Premier League meetings, including both of their last two visits to the Theatre of Dreams, and five of the last seven.
There is guaranteed to be one English team in the semi-finals after Tottenham and City were paired together, with the first leg to be played in London.
FC Porto, who won the competition in 2004 under Jose Mourinho, are confident they can spring an upset after last year's mauling.
We will play the first leg at home on Tuesday 9 April, kick-off 8pm, with the second leg to be played away on Wednesday 17 April, kick-off 8pm.
Scott Parker believes Liverpool have the deadliest strikeforce in the Premier League - but wants his struggling Fulham side to be on the front-foot when they host Jurgen Klopp's title challengers on Sunday.
Pi Day 2019: Celebrate 3/14 with deals on pizzas, pies and more
Show this Marie Callender's coupon on Pi Day and you'll get a free slice of pie with the purchase of any adult entrée. The 8-inch Margherita pizzas being offered for $3.14. (As for the pizza pies, there aren't any deals, unfortunately).
The swashbuckling Liverpool of last season could have pushed themselves into big trouble against the resilient and ruthless Bayern, but the Reds showcased their own newfound experience in Europe by controlling large periods of the two matches and outperforming their illustrious opponents. Back then, Liverpool won 5-0 in Portugal to start their route to the final. "I could not be further away from thinking it's the best draw because it isn't".
Juventus will go into this tie - a repeat of the 1996 final - as favourites to reach the semifinals, despite Ajax's stunning round of 16 victory over holders Real Madrid.
Ajax will play Juventus, first in Amsterdam on April 10, in a rematch of two previous finals.
City are looking to reach the last four of the Champions League for the first time under Guardiola and face a potentially hard test having been drawn to face Premier League rivals Tottenham Hotspur in next month's quarter-finals.
Juve have huge experience in the knockout stages of the Champions League, and the Italian champions are desperate to end their 23-year wait for their third European Cup.
The Champions League final takes place on 1 June in Madrid.